國家納米科學中心陳春英研究員做客第257期化苑講壇
報告題目：Interaction of Living Systems with Engineered Nanoparticles between Medical Benefit and Toxicity
報 告 人 ：陳春英研究員
報告時間：2017年5月11日（周四）上午9:30
報告地點：化學樓二樓一號會議室
邀 請 人 ：高中洪教授
報告人簡介：
陳春英，國家納米科學中心研究員，國家杰出青年科學基金獲得者，國家重點研發(fā)計劃納米科技重點專項首席科學家，國家自然科學基金創(chuàng)新研究群體骨干成員。1991年畢業(yè)于華中理工大學化學系，獲學士學位，1996年畢業(yè)于華中理工大學化學系，獲博士學位。長期從事納米材料的生物效應(yīng)與安全性的研究，是我國該領(lǐng)域的開拓者之一。致力于發(fā)展檢測生物體系納米材料轉(zhuǎn)化過程的創(chuàng)新方法，揭示典型納米材料的毒理學性質(zhì)及其健康效應(yīng)的作用機制，通過調(diào)控納米材料毒理學性質(zhì)實現(xiàn)其醫(yī)學應(yīng)用。
先后主持國家重點研發(fā)計劃納米科技重點專項、973項目課題、國家重大儀器專項課題、國家自然科學基金重點項目等。相關(guān)研究成果已在Nature Methods, Nature Commun, Chem Soc Rev, Accounts Chem Res, JACS, PNAS, Adv Mater, ACS Nano等國際著名學術(shù)刊物發(fā)表學術(shù)論文190余篇，他引超過6000 次。曾獲得國家自然科學二等獎、中國十大青年女科學家獎、入選國家百千萬人才工程、全球高引用科學家、以及中國科學院第五屆“十大杰出婦女”等榮譽稱號。
報告內(nèi)容：
Many nanomaterials are promising in biological detection, diagnosis, and therapy for diseases and have shown great potential for biomedical applications. It is important to obtain a better understanding of the uptake, trafficking, pharmacokinetics, clearance, and role of nanomaterials in biological systems, so that their possible undesirable effects can be avoided. Chemical speciation, dynamics and kinetics of nanomaterials in biological systems are extremely necessary since we have very limited knowledge. The intrinsic physicochemical properties of nanomaterials have decisive influence on their biological consequences. These properties include size, shape, surface charge, chemical composition, surface modification, metal impurities, agglomeration and dispersion, degradation, as well as the formation of “protein corona”. In this talk, I will summarize our recent progresses and will show how state-of-the-art approaches help us to understand the fate and behavior of nanomaterials in vivo. We will highlight the concept of safe-by-design for designing biocompatible nanomaterials with low-toxicity and high-efficacy.
