報(bào)告題目：基因進(jìn)化在化學(xué)中的應(yīng)用
報(bào) 告 人：王江云研究員
報(bào)告時(shí)間：2018年11月7日（周三）晚上7:00
報(bào)告地點(diǎn)：化學(xué)樓一號(hào)會(huì)議室
邀 請(qǐng) 人：劉紅梅教授
報(bào)告人簡(jiǎn)介：
王江云，中國(guó)科學(xué)院生物物理研究所研究員，國(guó)家杰出青年基金獲得者，教育部青年長(zhǎng)江學(xué)者。2003年獲美國(guó)伊利諾伊大學(xué)厄巴納-香檳分校博士學(xué)位，2003-2007年在The Scripps Research Institute從事博士后研究。2008年到中國(guó)科學(xué)院生物物理研究所工作，組建了以研究生物物理化學(xué)、合成生物學(xué)及化學(xué)生物學(xué)為主要方向的課題組，主要研究?jī)?nèi)容包括：1. 發(fā)展蛋白質(zhì)及RNA標(biāo)記的新方法，研究蛋白質(zhì)及RNA的定位、結(jié)構(gòu)、折疊以及相互作用。2. 研究含有金屬卟啉和銅離子的蛋白質(zhì)的結(jié)構(gòu)功能，并在此基礎(chǔ)上設(shè)計(jì)新的金屬酶。在國(guó)際一流期刊如Nat. Chem., Nat. Chem. Bio., Nat. Commun., JACS, Angew. Chem. Int. Ed.等上發(fā)表重要學(xué)術(shù)論文；在一些重要的國(guó)際會(huì)議如International Conference on Bioinorganic chemistry, Asian Biological Inorganic Chemistry Conference, IUPAC Chemical Biology Conference等上作大會(huì)報(bào)告或邀請(qǐng)報(bào)告；獲得第五屆中國(guó)化學(xué)會(huì)-英國(guó)皇家化學(xué)會(huì)青年化學(xué)獎(jiǎng)、第十三屆中國(guó)青年科技獎(jiǎng)。
報(bào)告簡(jiǎn)介：
Photosensitizers, which harness light energy to upgrade weak reductants to strong reductants, are pivotal components of the natural and artificial photosynthesis machineries. However, it has proved difficult to enhance and expand their functions through genetic engineering. Here we report a genetically encoded, 27 kD photosensitizer protein (PSP), which facilitates the rational design of miniature photocatalytic CO2 reducing enzymes. Visible light drives PSP efficiently into a long-lived triplet excited state (PSP*), which reacts rapidly with NADH to generate a super-reducing radical (PSP?), which is strong enough to reduce many CO­2 reducing catalysts. We determined the 3D structure of PSP? at 1.8 Å resolution by X-ray crystallography. Genetic engineering enabled the site-specific attachment of a nickel-terpyridine complex, and modular optimization of the photochemical properties of PSP, chromophore/catalytic center distance and catalytic center microenvironment, culminating in a miniature photocatalytic CO2 reducing enzyme which has a CO2/CO conversion quantum efficiency of 2.6%.
